Our Technology
Blood or Saliva based Cancer Diagnostics by Smart Analysis of Extracellular Vesicles
Extracellular Vesicles: Key Carriers of Biological Information
Extracellular vesicles (EVs) are small vesicles released by all cells into body fluids such as blood and saliva. They contain a variety of biological molecules – including proteins, lipids, and nucleic acids – and play a central role in cell-to-cell communication. Because of their origin-specific information, they serve as a „business card“ of the parental cell. Tumor cells are avid EV producers.
Our proprietary tumor signature technology enables the identification of specific molecular patterns in EVs that are associated with various cancers. Using advanced analytical methods, we can detect tumor-related changes early and with high precision – often before clinical symptoms appear.
Key Benefits of Our Technology
- Minimally invasive diagnostics: Analysis of blood and saliva samples
- High sensitivity and specificity: Detecting even the smallest tumor signals
- Rapid results: Efficient workflow suitable for clinical applications
Applications
We focus on cancer types which are commonly diagnosed in advanced cancer stages with a significantly worse overall survival. The aim is to achieve an early cancer detection with improved survival.
Head and Neck
Lung
Colon
Urothelial
Meet the Team
We are an interdisciplinary team of scientists, clinicians, and entrepreneurs committed to revolutionizing cancer diagnostics through EV technology. Our expertise spans molecular biology, bioengineering, bioinformatics, and clinical oncology, united by the mission to develop minimally invasive diagnostic tools that enable early cancer detection and advance precision medicine. We combine a passion for research with a drive to bring medical innovations from the lab to clinical practice faster.
Prof. Dr. Marie-Nicole Theodoraki, MHBA
Founder / CEO
Dr. Linda Hofmann
Founder / CTO
Tobias Theodorakis
Founder / COO
Scientific Expertise
Linda Hofmann, Tsima Abou Kors, Jasmin Ezic, Beate Niesler, Ralph Röth, Sonja Ludwig, Simon Laban, Patrick Schuler, Thomas Hoffmann, Cornelia Brunner, Valentin Medyany, Marie-Nicole Theodoraki
Comparison of plasma- and saliva-derived exosomal miRNA profiles reveals diagnostic potential in head and neck cancer
Front Cell Dev Biol. 2022
Linda Hofmann, Valentin Medyany, Jasmin Ezic, Ramin Lotfi, Beate Niesler, Ralph Röth, Daphne Engelhardt, Simon Laban, Patrick Schuler, Thomas Hoffmann, Cornelia Brunner, Edwin Jackson, Marie-Nicole Theodoraki
Cargo and functional profile of saliva-derived exosomes reveal biomarkers specific for head and neck cancer
Front Med. 2022
Marie-Nicole Theodoraki, Simon Laban, Edwin Jackson, Ramin Lotfi, Patrick Schuler, Cornelia Brunner, Thomas Hoffmann, Theresa Whiteside, Linda Hofmann
Changes in circulating exosome molecular profiles following surgery and (chemo)radiotherapy: early detection of response in head and neck cancer patients
Br J Cancer. 2021
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Luisa Tengler, Moritz Tiedtke, Julia Schütz, Karen Bieback, Stefanie Uhlig, Marie-Nicole Theodoraki, Katja Nitschke, Thomas Worst, Elena Seiz, Claudia Scherl, Nicole Rotter, Sonja Ludwig
Optimization of extracellular vesicles preparation from saliva of head and neck cancer patients
Sci Rep. 2024
Linda Hofmann, Malgorzata Harasymczuk, Diana Huber, Miroslaw Szczepanski, Grzegorz Dworacki, Theresa Whiteside, Marie-Nicole Theodoraki
Arginase-1 in plasma-derived exosomes as marker of metastasis in patients with head and neck squamous cell carcinoma
Cancers. 2023
Marie-Nicole Theodoraki, Linda Hofmann, Diana Huber, Cornelia Brunner, Thomas Hoffmann, Christian Idel, Jonas Fleckner, Karl-Ludwig Bruchhage, Ralph Pries
Plasma‑derived CD16 exosomes and peripheral blood monocytes as correlating biomarkers in head and neck cancer
Oncol Lett. 2023
Linda Hofmann, Marie Waizenegger, Ralph Röth, Stefanie Schmitteckert, Daphne Engelhardt, Patrick Schuler, Simon Laban, Thomas Hoffmann, Cornelia Brunner, Marie-Nicole Theodoraki
Treatment dependent impact of plasma-derived exosomes from head and neck cancer patients on the epithelial-to-mesenchymal transition
Fron Oncol. 2023
Marie-Nicole Theodoraki, Chang-Sook Hong, Vera Donnenberg, Albert Donnenberg, Theresa Whiteside
Evaluation of exosome proteins by on-bead flow cytometry
Cytometry A. 2021
Inga Beccard, Linda Hofmann, Jan Schroeder, Sonja Ludwig, Simon Laban, Cornelia Brunner, Ramin Lotfi, Thomas Hoffmann, Edwin Jackson, Patrick Schuler, Marie-Nicole Theodoraki
Immune suppressive effects of plasma-derived exosome populations in head and neck cancer
Cancers. 2020
Linda Hofmann, Sonja Ludwig, Julius Vahl, Cornelia Brunner, Thomas Hoffmann, Marie-Nicole Theodoraki
The emerging role of exosomes in diagnosis, prognosis, and therapy in head and neck cancer
Int J Mol Sci. 2020
Linda Hofmann, Sonja Ludwig, Patrick Schuler, Thomas Hoffmann, Cornelia Brunner, Marie-Nicole Theodoraki
The potential of CD16 on plasma-derived exosomes as a liquid biomarker in head and neck cancer
Int J Mol Sci. 2020
Marie-Nicole Theodoraki, Akihiro Matsumoto, Inga Beccard, Thomas Hoffmann, Theresa Whiteside
CD44v3 protein-carrying tumor-derived exosomes in HNSCC patients‘ plasma as potential noninvasive biomarkers of disease activity
Oncoimmunology. 2020
Marie-Nicole Theodoraki, Saigopalakrishna Yerneni, William Gooding, James Ohr, David Clump, Julie Bauman, Robert Ferris, Theresa Whiteside
Circulating exosomes measure responses to therapy in head and neck cancer patients treated with cetuximab, ipilimumab, and IMRT
Oncoimmunology. 2019
Marie-Nicole Theodoraki, Thomas Hoffmann, Edwin Jackson, Theresa Whiteside
Exosomes in HNSCC plasma as surrogate markers of tumour progression and immune competence
Clin Exp Immunol. 2018
Marie-Nicole Theodoraki, Thomas Hoffmann, Theresa Whiteside
Separation of plasma-derived exosomes into CD3(+) and CD3(-) fractions allows for association of immune cell and tumour cell markers with disease activity in HNSCC patients
Clin Exp Immunol. 2018
Marie-Nicole Theodoraki, Saigopalakrishna Yerneni, Cornelia Brunner, Joannis Theodorakis, Thomas Hoffmann, Theresa Whiteside
Plasma-derived exosomes reverse epithelial-to-mesenchymal transition after photodynamic therapy of patients with head and neck cancer
Oncoscience. 2018
Marie-Nicole Theodoraki, Saigopalakrishna Yerneni, Thomas Hoffmann, William Gooding, Theresa Whiteside
Clinical significance of PD-L1+ exosomes in plasma of head and neck cancer patients
Clin Cancer Res. 2018
Sonja Ludwig, Theofanis Floros, Marie-Nicole Theodoraki, Chang-Sook Hong, Edwin Jackson, Stephan Lang, Theresa Whiteside
Suppression of lymphocyte functions by plasma exosomes correlates with disease activity in patients with head and neck cancer
Clin Cancer Res. 2017
News
- HACK’N’TALK Womens Special
The Hack’n’Talk Women Special event showcased women in tech, featuring innovative pitches and an inspiring keynote lecture. - 3rd Price of the TUM IDEAward 2024!
BioExoTec won the 3rd priceof the IDEAward for EV-based diagnostics and innovative tumor signature technology. - Xplore Market Pioneer: Winner of the Public Vote!
We won the Public Vote Award at the Xplore Market Pioneer Program!
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